The result: Vinales was 0.188 seconds faster than Fabio Quartararo, who finished second, in 1:46.140 minutes. Third place went to Franco Morbidelli, ahead of Pedro Acosta and Jorge Martin. Marc Marquez was sixth, followed by Aleix Espargaro and Francesco Bagnaia. Alex Rins and Alex Marquez completed the top ten.
Marco Bezzecchi finished 13th, Brad Binder finished 14th and Enea Bastianini finished 18th.
On his way to a new best time in the last minutes of training, Pedro Acosta also crashed in Turn 10. He slid over the front wheel of his GasGas machine.
The weather: After heavy rain on Thursday and overnight into Friday, there were still a few wet patches on the track during the first MotoGP free practice session, but the racing line was already completely dry. A few dark clouds were visible over Mugello, but there was no further rain during the session. The outside temperature was 19 degrees, and 27 degrees was measured on the asphalt.